ISSN: 2639-2526
Authors: Bajaj A*
Invasive cribriform carcinoma breast emerges as a low grade subtype of invasive carcinoma breast. Neoplasm preponderantly (>90%) delineates a pure cribriform architecture or may represent as a mixed tumour composed of 10% to 90% of variant morphological subtype. Tumefaction is constituted of islands or nests of malignant epithelial cells demonstrating spherical or angulated contours or configure well defined cribriform spaces articulated by arches of epithelial cells, thereby delineating a sieve-like appearance with intercellular lumens impregnated with secretions. Miniature tumour cells display mild to moderate pleomorphism with absent nuclear atypia. Cribriform carcinoma breast is immune reactive to Oestrogen receptors(ER) or progesterone receptors (PR) and immune non-reactive to HER2 or diverse myoepithelial markers. Cribriform carcinoma breast requires segregation from neoplasms as adenoid cystic carcinoma, cribriform variant of ductal carcinoma in situ, collagenous spherulosis, well differentiated neuroendocrine tumour or well differentiated invasive breast cancer of no special type (NST). Neoplasm may be appropriately ascertained by mammography or ultrasonography of the breast. Cribriform carcinoma breast may be appropriately alleviated by primary surgical eradication of the lesion.
Keywords: Low Grade; Sieve-Like; Oestrogen/Progesterone+
