ISSN: 2578-4803
Authors: Godge GR*
A novel approach to oral and systemic drug delivery is nanaocochleate. It is a brand-new lipid-based system that offers a distinct technological platform appropriate for the systemic and oral delivery of numerous compounds with significant biologically therapeutic properties, such as medications, genes, and vaccine antigens. The technology of nanocochleate formulation is especially useful for hydrophobic macromolecules and small molecules with low oral bioavailability, as well as those that are negatively or positively charged. Research on the proof-of-principle of cochleate-mediated oral delivery of macromolecules and small molecule drugs is being conducted in suitable animal models using well-established, clinically significant drugs that are currently only administered by injection. Numerous obstacles that hindered the therapeutic potential of traditional drug delivery systems have been surmounted by phospholipids. Phospholipids, as formulation excipients, have been increasingly important. To address issues with the solubility and permeability of anti-cancer medicines, this study aims to provide an overview of the fundamental properties and applications of phospholipids in oral delivery systems, namely nanocochleates and drug-phospholipid complexes.
Keywords: Anti-Cancer Drug; Chemotherapeutic Agents; Cochleates; Nano-Carrier System; Novel Formulations; Oral Delivery; Phospholipids
