Anti-IgE Treatment in Allergic Rhinitis

Authors: Thabet W*

DOI: 10.23880/ooaj-16000295

Volume 9, Issue 2

Abstract

IgE plays a central role in the physiopathology of allergic rhinitis (AR). The binding of IgE-antigen immune complexes to mast cells triggers their degranulation and the release of inflammatory mediators, with the recruitment of other effector cells (eosinophils, basophils). This is the basis for the use of anti-IgE antibodies in the treatment of allergic diseases where we classically found high serum IgE levels.

Keywords: Allergic Rhinitis; Anti-IgE; Omalizumab

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