Diffuse Large B-cell Lymphoma with BCL6::MYC Translocation due to a Rare t(3;8)(q27;q24) – Literature Review with Prognostic Data

Authors: France A, Walkenhorst M, Zhang D, Gonzales PR and Golem S*

DOI: 10.23880/cprj-16000201

Volume 8, Issue 1

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype of non-Hodgkin lymphoma. It comprises a heterogeneous group of diseases that varies in morphology, immunophenotype and molecular features. Evaluation of prognostic factors is important in determining the risk category of patients newly diagnosed with DLBCL. Analysis of MYC, BCL2 and BCL6 gene rearrangements is essential in identifying high-risk patients. Lymphomas with MYC and BCL2 and/or BCL6 gene rearrangements are known as high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements and are associated with a poor clinical outcome. We report a rare t(3;8) BCL6::MYC gene rearrangement in a DLBCL patient and include survival information in these subsets of patients. This case also underscores the clinical utility of metaphase FISH in identifying such rare abnormalities which are indistinguishable by the interphase FISH assay using breakapart FISH probes.

Keywords: B-Cell Lymphoma; BCL6 Gene; Disease; Analysis; FISH

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