ISSN: 2578-4838
Authors: Sapkota LB*, Thapa S, Aryal G, Sharma S and Saru DB
Biochemical parameters like pH, pO2, pCO2, HCO3-, TCO2 and SO2 are frequently measured in critically ill patients with respiratory acidosis and alkalosis. These parameters have utmost importance in the assessment of ventilation, oxygenation and acid base status of these patients. The present study was undertaken to determine alteration of different biochemical parameters in patients with respiratory acidosis and alkalosis. This is a hospital based cross-sectional study conducted from May to December 2023, in the Department of Biochemistry, CMCTH. Arterial blood was collected and biochemical parameters like pH, pO2, pCO2, HCO3-, TCO2 and SO2 were measured using automated blood gas analyzer. Statistical analysis was done with SPSS version 21. This study showed that majority of the patients with respiratory acid-base disorder were females (58.1%) and elderly (41.8%). Respiratory acidosis and alkalosis were more common in elderly patients under age group 61-70 years followed by >70 years category. Respiratory acidosis was accompanied by alteration of various ABG parameters like low pH, low pO2, high pCO2, high HCO3-, normal TCO2 and normal SO2 levels while respiratory alkalosis was accompanied by high pH, low pCO2, low HCO3-, low TCO2, normal sO2 and normal pO2 levels. Respiratory acid-base disorders are common in hospital settings with ailing respiratory diseases like COPD, Pneumonia, TB and Sepsis with higher incidences among elderly patients. Respiratory acidosis and alkalosis should be treated promptly giving highest consideration to various biochemical parameters in order to reduce comorbidities and mortalities associated with these conditions.
Keywords: Respiratory Acidosis; Respiratory Alkalosis; ABG; pH
