Role of Sodium Nitroprusside in Primary PCI

Authors: Emara H*

DOI: 10.23880/oajc-16000207

Volume 8, Issue 1

Abstract

Sodium nitroprusside (SNP), a potent vasodilator with a rapid onset and short duration of action, has traditionally been used to manage acute hypertension in emergency settings. Its mechanism of action involves the release of nitric oxide (NO), leading to vascular smooth muscle relaxation. This article reviews the evolving role of SNP in primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). While SNP has demonstrated benefits in improving coronary flow and left ventricular function, concerns about potential ischemic injury through “coronary steal” effect necessitate careful consideration. Recent studies highlight its effectiveness in resolving no-reflow phenomena during PCI without significant adverse effects, suggesting that SNP can be a valuable adjunct in the management of AMI. The review also compares SNP with adenosine, another agent used during PCI, providing insights into their relative efficacy and safety profiles.

Keywords: Sodium Nitroprusside; PCI; Acute Myocardial Infarction; Coronary Steal

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