Effect of Ethanol Extract of Beta Vulgaris on Liver Enzymes of Monosodium Glutamate-Induced Hepatotoxicity in Wistar Rats

Authors: Uchendu IK*

DOI: 10.23880/beba-16000240

Volume 8, Issue 2

Abstract

Objective: Certain drugs may cause liver injury when administered even within the therapeutic ranges. Monosodium glutamate (MSG) has been studied and identified to have some harmful effect on the liver which may lead to hepatotoxicity. The Effect ethanol extract of Beta vulgaris (EEBV) on liver enzymes of MSG-induced hepatotoxicity in wistar rats was evaluated. Method: The total number of 30 wistar rats was used in this study. The 30 wistar rats were categorized into 5 major groups, A, B, C, D, and E. Each groups have 6 wistar rats and specifically given a distinct treatment but the same standard diet. Group A served as Normal control and received no treatment; group B received MSG (4mg/kg) without treatment, group C received MSG (4mg/kg) + EEBV (200mg/kg), group D received MSG (4mg/kg) + EEBV (400mg/kg) and group E received MSG (400mg/kg) + Hydrocortisone (100mg/kg). Throughout the experiment, the body weight of the rats was recorded every week until week 6.Blood samples and liver tissues were collected for biochemical and histopathology analyses for hepatic injury using standard methods. The statistical analysis was done using ANOVA and the multiple comparison was done using SPSS. Difference were considered significant at p<0.05 level of significance. Result: Findings from the study, monosodium glutamate induced a significant hepatotoxicity, which was significantly ameliorated by low and high doses of ethanol extract of Beta vulgaris . Conclusion: Beta vulgaris is a potent plant for treatment of hepatotoxicity against monosodium glutamate.

Keywords: Ethnopharmacology; Hepatoprotection; Hepatotoxicity; Liver; Beta Vulgaris; Monosodium Glutamate

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