Neuropathic Pain

Authors: Haider R*, Mehdi A, Das GK, Ahmed Z and Zameer S

DOI: 10.23880/ijbp-16000256

Volume 9, Issue 2

Abstract

Neuropathic pain, caused by damage to the nervous system, presents a major challenge in clinical care due to its complex nature. This review focuses on the mechanisms and current treatment strategies for neuropathic pain, particularly in conditions such as diabetes and other chronic neurological disorders. Neuropathic pain often manifests as spontaneous pain, hyperalgesia, and allodynia. Diagnosis involves a comprehensive patient history, physical examination, and specialized tests. Although pharmacologic treatments such as anticonvulsants and antidepressants are common, their efficacy is often limited by side effects. Non-pharmacologic therapies, including physical therapy and neuromodulation, provide additional relief. Emerging treatments, like nerve growth factor inhibitors, show promise in early trials. Personalized medicine, incorporating genetic and molecular insights, could revolutionize future treatment approaches. Continued research into these mechanisms is crucial for improving patient outcomes.

Keywords: Neuropathic Pain; Chronic Pain; Nervous System; Pathophysiology; Diagnosis; Treatment; Pharmacologic Interventions; Non-pharmacologic Treatment; Emerging Therapies; Personalized Medicine

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