ISSN: 2577-4328
Authors: Lahir YK*
General physiology is the basis of basic and applied aspects of life processes and moleculo-biochemical aspects that ensures the survival of species efficiently. There is a need to maintain specific amount and numbers of metabolites in the body fluid and the fluid present in the organs. This needs a specific check on the body fluid that provides the required metabolites and removes unwanted ones. For this scrutiny, there is something like a ‘check post’ and it is referred to as ‘blood organ/tissue barrier’. Further, this ensures the restoration of appropriate ambient environment for the ongoing physiological processes in an organism. Structural, biochemical and molecular aspects of blood organ barriers have potential to illustrate on the survival mechanisms. Further, biotechnological research, artificial mode of physiological techniques and the technological advancement help to understand the intricacies of various physiological mechanisms occurring in the life activities and the remedial aspects in cases of pathogenesis. For normal physiological functioning a suitable physiological homeostasis is an important basis. The respective balanced biochemical and molecular interactions depend on processes like paracellular diffusion of metabolites, activated transport of hydrophobic and hydrophilic metabolites and drugs from the circulating blood stream. There is a specific need of an effective drug therapy along with appropriate drug delivery system that can regulate the correct dose of drug at the site to meet the remedial parameters while dealing with pathogenesis and dysfunctioning of the organ. The investigations relating blood barrier are significant while investigation the toxicological and pathological aspects of a given organ.
Keywords: Blood Tissue Barrier; Pericytes; Tight Junctions
