ISSN: 2577-4360
Authors: Amirova M*, Dadashova A, Melikova N, Mammаdova F, Kerimova I, Yagubova V and Orujov A
Taking into account the information on the mechanism of of SARS-CoV-2 development, during treatment, it is advisable to pay attention to inhibition of viral replication; reduction hypoxia; elimination drug poisoning and toxic, allergic consequences; add antioxidant therapy to prevent formation of reactive oxygen species (ROS) at recovery phase and hook up anti-inflammatory therapy. This goal could be achieved through the administration of antioxidants with anti-viral properties. For example, using superoxide dismutase mimics metalloporphyrins, metallocorroles, Mn biliverdins, Mn cyclic polyamines, Mn salens, metal oxides/salts and inducers of antioxidant protection. It is also possible to increase the antioxidant enzymes genes expression or the activity of the enzyme itself. Patients taking antibiotics for SARS-CoV-2 were more susceptible to exacerbations due to opportunistic infections, so alternatives to antibiotics with high efficacy and well-absorbed antioxidant properties are more appropriate. In this regard, vitamin C, N-acetylcysteine, and glycine, as well as melatonin, quercetin, astaxanthin, glutathione, fat-soluble vitamins, polyphenols, unsaturated fatty acids, and a number of other substances with high anti-inflammatory effects exhibit positive effect.
Keywords: Antioxidants; Reactive Oxygen Species (ROS); SARS-CoV-2; Cytokine Storm; Vitamins
