Advancements in Diagnosing and Treatments Plasmodium knowlesi: Challenges and Innovations

Authors: Moumaris M

DOI: 10.23880/izab-16000622

Volume 7, Issue 5

Abstract

Diagnosing malaria, especially Plasmodium knowlesi, is challenging due to its similarity to other species, which often results in misdiagnoses. While rapid diagnostic tests are unreliable and expensive PCR methods, loop-mediated isothermal amplification (LAMP) presents an option that needs further validation. Effective diagnostics are crucial for accurate treatment. Plasmodium knowlesi can be fatal if untreated and is typically managed with artemisinin-based therapies, with no observed drug resistance, highlighting the need for timely diagnosis. Plasmodium knowlesi is the main in malaria research in vaccine and drug testing. However, the focus is shifted to pig-tailed macaques, showing consistent replication and immune responses. A new CRISPR/Cas9 technique enhances chromosome segregation in rodent malaria parasites, advancing genetic research with broader applications.

Keywords: Plasmodium knowlesi; Malaria; Infection; Diagnosis; Treatments

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