ISSN: 2574-8009
Authors: Shetty M, Ghadage M, Rungta S, Basu D, Banerjee R*, Muchhala S, Katare S, Kotak B, Dhanaki G and Mitra M
Objective: To compare the effectiveness of omeprazole versus pantoprazole for satisfactory resolution of GERD/APD symptoms. Design: This multicentric, real-world evidence (RWE) study was conducted using data extracted from electronic medical records (EMRs) of anonymized, treatment-naïve, adult GERD/APD patients treated with proton pump inhibitors (PPIs) omeprazole or pantoprazole. The primary endpoint was the proportion of patients achieving satisfactory symptom resolution with 20mg/day omeprazole versus 40mg/day pantoprazole after 14(±7) and 28(±7) days. Secondary endpoints included lifestyle-based patient profile, proportion of patients achieving satisfactory symptom resolution with 40mg/day omeprazole versus 80mg/day pantoprazole after 14(±7) and 28(±7) days, response of patients with comorbidities or regular smoking/ drinking habits, and safety/tolerability of treatment. Results: Data from 300 EMRs for each PPI was analyzed. A higher proportion of patients achieved complete symptom resolution with omeprazole(20mg) than pantoprazole(40mg); the difference was statistically significant for heartburn (21.65% versus 4.85%, p<0.001), regurgitation (33.51% versus 22.47%, p=0.011), and epigastric pain (31.44% versus 16.74%, p<0.001) among others, at 14(±7) days, and for heartburn (p<0.001) and epigastric pain (p<0.001) at 28(±7) days. Omeprazole(40mg) was significantly more effective than pantoprazole(80mg) for complete resolution of bloating at 14(±7) days and of regurgitation and bloating at 28(±7) days. In patients with hypertension, diabetes, or cardiac conditions, omeprazole resulted in better symptom resolution than pantoprazole. In patients with obesity or regular smoking/drinking habits, the PPIs were comparably effective. No adverse events were reported. Conclusion: Omeprazole(20mg) was safe and well-tolerated in patients and was significantly more effective than pantoprazole(40mg) in resolving GERD/APD symptoms at 14(±7) and 28(±7) days.
Keywords: Omeprazole; Pantoprazole; Proton Pump Inhibitor (PPI); Gastro-Esophageal Reflux Disease (GERD); Acid Peptic Disease (APD); Effectiveness; Safety; Tolerability; Real-World Evidence (RWE)
