ISSN: 2578-5044
Authors: Khansari N*
Interleukin-11 (IL-11) is a crucial cytokine in regenerative medicine and tissue engineering due to its role in tissue repair, cellular regeneration, and immune responses. It involves various biological processes, including hematopoiesis, inflammation, and remodeling. IL-11 is essential for maintaining progenitor cell populations during regeneration, enhancing wound healing, and modulating fibrotic responses during tissue repair. It also influences the immune microenvironment, promoting a reparative M2 phenotype conducive to tissue healing. IL-11’s role in bone metabolism and repair is gaining attention, as it regulates the activity of osteoblasts and osteoclasts, influencing bone homeostasis and regeneration. IL-11’s therapeutic applications extend beyond direct tissue repair and hold promise for improving the efficacy of biomaterials used in tissue engineering. However, the potential for IL-11 to induce adverse effects, such as excessive fibrosis, necessitates careful consideration in therapeutic applications. The interplay between IL-11 and the extracellular matrix (ECM) is another critical aspect of its role in regenerative medicine.
Keywords: Regenerative Medicine; Tissue Engineering; Interleukin-11 (IL-11)
