ISSN: 2642-6145
Authors: Jagtap SV¹*, Jagtap SS², Dodia D³, Bandodkar N³, Patil P³ and Jadhav AS⁴
Background: Schwannoma is a benign, well-circumscribed tumor attached to peripheral nerves, consisting of a clonal population of Schwann cells. Cellular Schwannomas is a relatively uncommon but significant variant of Schwannoma, have a higher cellularity and mitotic rate than conventional Schwannomas. Case Reports: Case 1 presented in a 22 year female patient presented with headache, vertigo, facial numbness and loss of balance of one month duration. Past history, she was case of cerebellopontine angle tumor (Vestibular Schwanomma) operated for the same in two year back. MRI brain plain and contrast findings were, a well-defined lobulated extra axial mass lesion noted at left CP angle measuring 3.2x3.3x2.7cm. Patient treated with surgical excision of left cerebellopontine space occupying lesion. On histopathological examination reported as vestibular Schwannomas-cellular variant. Case 2 was a 55 year female patient presented with headache, ataxia, giddiness and dementia. MRI Brain showed a well- defined hypointense, heterogenously hyperintense solid-cystic extra-axial lesion in left cerebello-pontine cistern measuring 2.4 x 2.8 x 2.5 cm. Excision of left cerebellopontine space occupying lesion was done. On gross, irregular, grey-white, soft tissue mass lesion 2.5x2x0 cm. On histopatholical findings reported as vestibular schwannoma-cellular variant. Immunohistochemistry revealed S100, SOX10 positive and Ki-67 proliferation index is moderately elevated (3%). Conclusion: Cellular Schwannomas is an uncommon variant of Schwannoma. Local recurrence in cellular schwannoma may observe related to its high cellularity, increased mitotic activity, resection extent and tumor size. Herewith presenting this cases for its clinical, radio imaging, and histopathological findings.
Keywords: Vestibular Schwannoma; Peripheral Nerve Sheath Tumor; Cellular Schwannoma; Radio Imaging
