Case of Hairy Cell Leukemia – Rare Presentation

Authors: Ramnik Singh* , Billawaria S and Alexender R

DOI: 10.23880/cprj-16000211

Volume 8, Issue 1

Abstract

Hairy cell leukemia (HCL) is indolent chronic B-cell neoplasm involving the bone marrow, spleen, and peripheral blood. The complete blood count reveal pancytopenia. On peripheral blood examination reveal small to medium sized lymphocytes having circumferential villous projection with reniform nuclei and moderate amount of cytoplasm. Clinical features which patient usually present is Fever, generalized weakness and abdominal pain. On clinical examination may also reveal massive splenomegaly. Most common median age of presentation is approximately 55 year. Diagnosis for hairy cell leukemia is based on morphology, immunological phenotyping by flow cytometry, immunohistochemistry on trephine biopsy, and the presence of BRAFV600E mutation.

Keywords: Hairy Cell Leukemia; Flow Cytometry; Spleenomegaly

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