A Systematic Review on Molecular Pathophysiology Involved in Chronic Kidney Disease and the Role of Animal Models in Drug Discovery to Manage in Chronic Kidney Disease - An Update

Authors: Sharma UR*

DOI: 10.23880/oajun-16000267

Volume 9, Issue 4

Abstract

Chronic kidney disease (CKD) is a life threatening condition that causes progressive loss of kidney function. It is one of the leading causes of death and affects about 10% of the population worldwide. CKD poses a great challenge for societies as well as health care systems. Currently, there are only a few treatments being developed for CKD, several of which have failed to improve renal outcomes. CKD is caused due to multiple factors whose mechanism is incompletely understood. Hence, various animal models have been established as an approach towards clarifying the pathogenesis and underlying mechanism of CKD. In the present review, we discuss the possible mechanisms of CKD along with the animal models used to mimic the human CKD in order to have a better understanding of generation and progression of CKD.

Keywords: Renal Disease; Diabetes; Hypertension; Nephropathy; Fibrosis; CKD Models; Diabetic Kidney Disease

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