ISSN: 2574-7770
Effect of Acute Phase Reactants in Pathogenesis of Newly Diagnosed Type 2 Diabetic Patients and Patients under Treatment by Oral Hypoglycemic Drug for Minimum 5 Yrs
Acute phase response which is predominately cytokine-mediated is observed to be closely involved in the pathogenesis of type 2 diabetes. Since maximum world populations are at high risk of developing diabetes, we tested this hypothesis by estimating circulating acute phase proteins type 2 (T-2) diabetic patients and type 2 diabetic patients under oral hypoglycemic drugs for duration of at least 5 years. The acute phase proteins, α1- antitrypsin, α1- acid glycoprotein, ceruloplasmin and fibrinogen were estimated in the plasma in newly diagnosed 25 T-2 cases and 25 T-2cases under oral hypoglycemic agent for at least 5 years Thirty normal controls to match the age and sex of the test groups were also studied. The levels of these proteins were correlated with their BMI and random plasma glucose values. In comparison with the controls, the values of all the four proteins studied were significantly elevated in the T-2 patients (p<.00001) and reduced significantly except α1- acid glycoprotein and ceruloplasmin. Interestingly, no correlation was found with BMI or the degree of hyperglycemia in either of the types. A low grade inflammatory process is definitely implicated in the pathogenesis of type 2 diabetes. This line of pathological basis should be further explored for diagnosis, management and follow up.
Keywords:
α1- acid glycoprotein; α-1 antitrypsin; Fibrinogen; Ceruloplasmin
