International Journal of Forensic Sciences (IJFSC)

ISSN: 2573-1734

Review Article

A Forensic Appraisal of Neoteric Hyphenated Techniques for Separation and Detection of Narcotic Drugs

Authors: S Thangadurai*, , B Sithi Asma , A Palanimurugan and A Cyril

DOI: 10.23880/ijfsc-16000430

Abstract

Narcotic drugs are traditionally been identified on basis of chromatographic-hyphenated techniques in instrumental analysis.
Nowadays, contemporary neoteric chromatographic hyphenated techniques have received ever-increasing attention because
the principal means to unravel complex analytical problems. A legal examination is a term articulated for examination of all
sorts of violations that leads to the prove for any sort of wrong doing as a conclusion of the suspect. Forensic laboratories
drugs are identified and separated by TLC, HPLC, HPTLC, GC, LC and known hyphenated techniques which are like HPLC-MS,
HPTLC-MS, GC-MS, and LC-MS-MS etc. give reliable and confirmatory leads to drugs identification. HPLC-MS is more preferred
method for separation and detection of narcotic drugs. The drawback of HPLC which it requires more solvent as compared to
HPTLC. These techniques provide efficient, quick and straightforward method for detection and separation of narcotic drugs
and psychotropic substances (NDPS). Analytical chemists face a challenging task in separating, identifying, and determining
illicit drugs in pills and biological fluids. There is an increasing need to create advanced methodologies to reduce analysis time,
improve sensitivity, and progress towards green chemistry. The hyphenated techniques help in low level detection, highly
specific detection, and precise and accurate results for the forensic investigations.

Keywords: Chromatography; Narcotic Drug; NDPS; Forensic; Biological Fluids; Separation

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