An Update on Primary Adult Hypogonadism in Elderly Males Secondary to Inflammaging: A Narrative Review

Authors: Kaur KK* , Allahbadia GN and Singh M

DOI: 10.23880/oajg-16000298

Volume 10, Issue 1

Abstract

With the escalation of life expectancy, it is obvious that greater prevalence of conditions like late-onset hypogonadism (LOH) are bound to be encountered in an escalating manner in elderly males. LOH the properties of reduction in testosterone quantities in addition to possess significant influence in physical along with mental health. Whereas, the etiological factor of LOH continue to uncharted, an escalating interest is existent in the evaluation of part of inflammageing in its production. Inflammageing portrays theposit of chronic low grade systemic inflammation which takes place at the time of ageing. Such inflammatory status has been held responsible in the generation of variable age associated diseases. Separate cellular along with molecular mechanistic modes have been isolated to aid in inflammageing inclusive of cellular senescence, mitochondrial impairment, autophagy abnormalities in addition to immune senescence alias immunosenescence. Having reviewed earlier the part of inflammageing in addition to immunosenescence in ovarian ageing & variable infectious diseases we provide a a narrative review in reference to LOH. Further we deal with the, recent advance in its therapies inclusive of adrenomedullin, SS-31,amitochondria targeting peptide Leydig cells transplantation with use of CRISPR/Cas or use of variable stem cells.

Keywords: Late Onset Hypogonadism (LOH); Inflammageing; Immunosenescence; Mitochondrial Impairment; Leydig Cells Transplantation

View PDF