Haematology International Journal (HIJ)
ISSN: 2578-501X
Research Article
Variation in Red Blood Cell Count and Red Cell Distribution Width
(RDW) among Dialysis Adherent Chronic Kidney Disease Patients
Abstract
Background: Chronic Kidney Disease (CKD) is a prevalent condition associated with high morbidity, especially in dialysis patients. Anemia, a common complication, is linked to RBC count and red cell distribution width (RDW). However, the relationship between these parameters and CKD stages, dialysis duration, and outcomes is not well explored.
Objective: This study aimed to assess variations in RBC count and RDW in dialysis-dependent CKD patients and their correlation with CKD stage, dialysis duration, and clinical outcomes.
Methods: A cross-sectional study of 120 CKD patients undergoing hemodialysis for at least 6 months was conducted. Peripheral blood samples were analyzed for RBC count and RDW. Demographic and clinical data, including age, gender, comorbidities, dialysis duration, and CKD stage, were reviewed. Statistical analyses included Pearson’s correlation, t-tests, and multivariate regression.
Results: The mean RBC count was 3.2 ± 0.6 million/μL, and RDW was 16.2 ± 2.4%. A significant inverse correlation between RBC count and RDW was found (r = -0.42, p < 0.01). Advanced CKD stages (4-5) and longer dialysis durations (≥3 years) were linked to lower RBC counts (p < 0.05). Multivariate analysis identified dialysis duration, CKD stage, and comorbidities like diabetes as independent predictors of RBC count and RDW (p < 0.01).
Conclusion: RBC and RDW levels vary in dialysis-dependent CKD patients. Advanced CKD stages and longer dialysis durations are associated with poorer hematological profiles, suggesting RDW as a potential biomarker for anemia severity. Further research is needed for anemia management in this population.
Keywords: Chronic Kidney Disease; RBC Count; RDW; Dialysis; Anemia; Hemodialysis; Biomarkers
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