Synergistic Effect of Combined Leaf Extract of Vernonia amygdalina, Ocimum gratissimum, and Zingiber officinale Tuber on Phytochemical Profile, Antioxidant Activity, Serum Insulin, and Biochemical Parameters in Streptozotocin-Induced Diabetic Rats

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DOI: 10.23880/doij-16000297

Volume 10, Issue 1

Abstract

The use of poly-herbal therapy, which involves achieving maximum therapeutic efficacy against several diseases by combining various substances from different plant sources, has received substantial attention for several decades. This research aimed at investigating the synergistic effect of combined leaf extract of Vernonia amygdalina, Ocimum gratissimum, and Zingiber officinale tuber on phytochemical profile, antioxidant activity, Serum Insulin, and Biochemical Parameters in Streptozotocin- Induced Diabetic Rats There were four equal groups of sixteen albino rats. Plaque therapy was administered to Group 2 (diabetic control) and Group 1 (normal control), respectively. For 28 days, groups 3 and 4 of the diabetes tests were given metformin and a combination of Vernonia amygdalina, Ocimum gratissimum, and Zingiber Officinael extracts at a dosage of 400mg/kg b. w., respectively. Blood and pancreas were taken when the animals were sacrificed for hematological and histological evaluations, as well as for serum glucose, insulin, liver function, renal function, electrolytes, and histopathology studies. A considerable rise in the animals' body weight (p

Keywords: Diabetes; Vernonia Amygdalina; Ocimum Gratissimum; Zingiber Officinale; Streptozotocin; Rats; Phytochemicals; Antioxidants; Insulin

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