The Effect of Drinking Water with a High Content of Antimony and Arsenic on the Dynamics of their Distribution in the Kidneys and the Renal Excretory Function in Rats

Authors: Aizman RI , Ogudov AS and Novikova II

DOI: 10.23880/oajun-16000270

Volume 9, Issue 4

Abstract

This article is devoted to the study of the dynamics of antimony accumulation in renal tissue and the assessment of the renal excretory function in Wistar rats following a subchronic 90-day experiment with consuming model water from a man-made reservoir formed at a gold mining plant with a different ratio of subthreshold and threshold concentrations of arsenic and antimony. It is shown that the dynamics of the distribution of antimony ions in the renal tissue of rats is determined by the exposure time and the ratio of concentrations of these ions in water. Depending on this, the nephrotoxic effect, characterized by changes in diuretic, ionuretic, and osmoregulatory functions, manifests itself in different ways - increased fluid excretion and decreased ionuresis; absence of changes in urination and increased osmolality and natriuresis, or decreased excretion of osmotically active substances at different times of chronic intoxication formation. Changes in renal function are not detected at rest on an empty stomach, but manifest themselves only under conditions of a water load test (3% of body weight), when it is necessary to activate reserve mechanisms for regulating the water-salt balance. Thus, for the first time in warm-blooded animals, the spectrum of manifestations of the nephrotoxic effect is shown in conditions of prolonged consumption of drinking water with a different ratio of subthreshold and threshold concentrations of arsenic and antimony.

Keywords: Antimony; Arsenic; Model Drinking Water; Renal Excretory Function; Ion Distribution in Renal Tissue

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