Gallic and Citric Acid Present in the Peels of Tropical Fruits as an Alternative in the Fight against Cancer

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DOI: 10.23880/apct-16000258

Volume 10, Issue 2

Abstract

Most drugs exert their effects by interacting with proteins that serve specific biological functions. For instance, if a protein is involved in energy production, a drug may bind to it—what chemists refer to or inhibit its energy-producing capabilities. In both scenarios, the drug disrupts the dynamic equilibrium of the organism, leading to a biological effect. With this context in mind, this study utilized the Autodock Vina (integrated into Chimera) program to evaluate the affinity of two compounds found in citrus peels: citric acid and gallic acid. These compounds were tested against a protein known to inhibit the alpha subunit of the tubulin dimer, which is recognized for its ability to kill cancer cells. The findings revealed that gallic acid exhibits a greater affinity to pironetin, a compound identified as the ideal inhibitor drug for this subunit. This suggests that gallic acid could be a potential candidate for treating tumor cell lines.

Keywords: Audotock vina; Citric acid; Gallic acid; Alpha tubulin

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