Antifungal Activity of New Acetophenone Derivatives

Authors: Khudaverdi G* , Nurana A , Farid N , Ibrahim M and Mirzayeva S

DOI: 10.23880/oajmb-16000321

Volume 11, Issue 1

Abstract

The emergence of antifungal resistance among Candida species has created an urgent need to develop new antifungal agents. In this study, four newly synthesized organic compounds: 4-(3-methoxyphenyl)-2,6-diphenylpyridine (I), 4''Nitro-5'-oxo-Nphenyl- 2',3',4',5'-tetrahydro-[1,1':3',1''-terphenyl]-4'-carboxamide (II), (2,4-bis(3-methoxyphenyl)-6-phenylcyclohexane-1,3- diyl)bis(phenylmethanone) (III) and 4''-methoxy-5'-oxo-N-phenyl-2',3',4',5'-tetrahydro-[1,1':3',1''-terphenyl]-4'-carboxamide (IV) were evaluated for their antifungal activity against three clinically relevant Candida species: Candida albicans BDU MI – 44 and C. guilliermondii. BDU-217, C. tropicalis BDU LK-30. Antifungal efficacy was assessed by agar well diffusion method, and results were expressed as zones of inhibition (mm). All tested compounds exhibited inhibitory activity against C. albicans. Compounds I, II, and IV exhibited 1.2-1.3-fold greater inhibitory activity than compound III. Compound III was also active against C. guilliermondii, while the remaining compounds were inactive. None of the compounds exhibited inhibitory activity against C. tropicalis. These results indicate that acetophenone derivatives I, II, and IV possess selective antifungal activity, offering potential for further development as inhibitory agents against Candida albicans infections.

Keywords: Antifungal Activity; Acetophenone Derivatives; Candida Species

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