ISSN: 2574-7770
Authors: Aktas V , Gurol AO , Durak S , Aksoyer Sezgin SB , Celik F , Diramali M , Ozyavuz MK , Ergen HA and Zeybek U
Obesity is a multifactorial global health concern strongly associated with metabolic disorders, including type 2 diabetes mellitus, cardiovascular diseases, and metabolic syndrome. Genetic determinants, particularly polymorphisms in the PPARγ and TRHR genes, have been implicated in susceptibility to obesity across diverse populations. This study aimed to investigate the genotype distributions of PPARγ (rs1801282) and TRHR (rs16892496) polymorphisms and to evaluate their associations with metabolic parameters in a Turkish cohort. Genotyping was performed using real-time polymerase chain reaction in a total of 239 individuals, comprising 160 patients with obesity and/or diabetes and 79 healthy controls. In the non-diabetic obese subgroup, individuals carrying the GG genotype showed significantly different body mass index (BMI) values compared with those carrying the CC and CG genotypes (p = 0.008). In the control group, carriers of the C allele exhibited significantly higher high-density lipoprotein (HDL) cholesterol levels than carriers of the G allele (p = 0.034). Furthermore, BMI values were significantly lower in A allele carriers compared with C allele carriers within the control group (p = 0.026). These findings suggest that genetic variation in PPARγ and TRHR may contribute to obesity- and diabetes-related phenotypes and could influence disease susceptibility. However, further large-scale, multi-ethnic studies are warranted to validate these associations and elucidate the underlying molecular mechanisms.
Keywords: Polymorphism; PPAR-γ; TRHR; Diabetes; Obesity