ISSN: 2574-7770
Triple Therapy with Empagliflozin, Linagliptin and Gliclazide in a Patient who Refuses Insulin: New Solutions to an Old Problem
Background: Insulin therapy refusal is a common subject in the routine of endocrinologists. New therapeutic options can work around this issue.
Objective: To report a case of insulin therapy refusal in a type 2 diabetes patient and how this was handled.
Design: Interventional case report with clinical and laboratory correlation. Case Report: 54-year-old man receiving Metformin, 1.7g/d for 2 weeks. Triple oral therapy was considered after refusing insulin. Clinical evaluation and assessment of metabolic profile were completed on admission and 3 months later. The outpatient record was also reviewed.
Discussion: The triple therapy with Gliclazide, Empagliflozin and Linagliptin promoted laudable glycemic control, besides additional benefits in the blood pressure and weight loss.
Conclusion: Facing the patient’s refusal or disinterest to use insulin, new classes of oral antidiabetic drugs are required
Keywords:
DPP-4 inhibitors; SGLT2 inhibitors; Combination therapy; Type 2 diabetes