ISSN: 2577-4379
Modern Immunotherapy for Gastric Cancer
Authors:
Horino K1, Baba H2 and Shimada S1*
Gastric cancer is one of the most common malignant diseases in the world. Although its prognosis has improved markedly due to developments in surgical techniques and several perioperative treatments, only a few patients survive. Recently, immunotherapy has been recognized as a novel type of therapy for gastric cancer. In contrast to conventional therapies, immunotherapies produce anti-tumor effects by strengthening the immune functions of tumor cells. Immune checkpoint blockade therapy is a novel immunotherapy. The most important immune checkpoint molecules are cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) and programmed cell death-1 (PD-1). Antibodies against these molecules are currently approved for use as treatments for gastric cancer. Clinicians should use both immune checkpoint blockade therapy and conventional treatments to treat gastric cancer.
Keywords:
CTLA-4; PD-1; Gastric Cancer; Immunotherapy
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