Genetic Evidence in Behcet Disease Pathogensis

Authors:

Abdelmoktader A*

Volume 2, Issue 1

Abstract

Behcets disease (BD) is considered are lapsing multisystem chronic inflammatory disorder. It has a worldwide distribution, but it is more prevalent in Mediterranean countries. The cause of BD remains unknown. Environmental factors, infectious agents, and immune dysregulation, as well as genetic factors, have been studied extensively. The presence of familial cases, the geographic and ethnic distribution of the disease, and the association of BD with the MHC class I antigen HLA-B51 have been cited as evidence of a genetic basis of the disease.

Keywords:

Behcets disease; HLA; HLA-B*51; MHC region; Non-HLA genes; TNF gene; MICA gene; ICAM-1; MBL; N-Acetyltransferase; ENOS; VEGF

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