Insulin Resistance, Obesity and Polycystic Ovarian Syndrome in Diabetic Patients

Authors: Aziz KMA*

DOI: 10.23880/doij-16000173

Volume 3, Issue 1

Abstract

Ingestion of diets with high fats or lipids is associated with obesity and increased storage of triglycerides at sites other than adipose tissue, including skeletal muscle, liver, the heart, and kidney. These changes cause chronic elevations in circulating free fatty acids and triacylglycerols (TAG). Extensive research has shown that adipose tissue is an important endocrine organ. Adipose cells produce a variety of hormones and cytokines (referred to collectively as “adipokines”) which regulate both lipid and glucose metabolism and play a direct role in development of insulin resistance and diabetes. Some of them are peptide hormones such as adiponectin (also Acrp30) and resistin, and proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-α (TN-α) [1-7].

Keywords: Diabetic Patients; Obesity; Polycystic Ovarian Syndrome

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