Approach to a Guideline for Epigenetic Therapy in the High Risk Cancer Setting

Authors: Saeed Taheri

Volume 2, Issue 1

Abstract

The term ‘epigenetics’ had been originally described by Waddington in 1939; and after substantial changes in the definition, it has been finally defined as “the study of “heritable changes in gene expression, capable of altering cellular phenotype and function independent of alterations in DNA sequence”, which has now been a focus of intensive research as a promising ambition for the management of malignant disorders [1]. There has been a large number of clinical trials investigating effects of therapeutic agents targeting epigenome of cancer patients, though the majority of them are early phase studies and there is scarcity of powerful data coming from randomized clinical trials with large patient populations in this setting. 

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