Evaluation of Antipyretic and Analgesic Effects of Aqueous Extract of Leaves of Vernonia Amygdalina Del. (Asteraceae)

Authors:

Elion Itou RDG^1,2*, Etou Ossibi AW^1,2, Nsonde Ntandou GF ^1,2, Morabandza CJ^1,3, Mayela Nkouka SHJ, Bokia CB¹ and Abena AA¹

DOI: 10.23880/beba-16000125

Volume 2, Issue 2

Abstract

Objective: This study aims to evaluate the antipyretic and analgesic effects of leaves of V. amygdalina collected in Brazzaville-Congo.

Method: The antipyretic effect was induced using brewer's yeast induced pyrexia. The results obtained show that paracetamol and the aqueous extract of V. amygdalina at the doses used (400 and 800 mg/kg) increased significantly (p < 0.05; p < 0.01 and p < 0.001) pyrexia induced by brewer's yeast from the second hour to the fifth hour of observation. Analgesic effect was evaluated by using the acetic acid-induced writhing, the pressure induced by the analgesymeter as well as the pain induced by formaldehyde. The results obtained show that the aqueous extract at the doses used (400 and 800 mg/ kg) significantly (p < 0.05; p < 0.001) reduces the number of abdominal writhing induced by acetic acid, significantly increased the latency time of the paw of the animal at the pressure induced by the analgesic meter (p <0.05 and p <0.01) and also significantly decreased the number of licking or biting of the paw compared to the control (p< 0.001).

Conclusion: This result suggests that the aqueous extract of leaves of V.amygdalina at doses used (400 and 800 mg/kg) has an antipyretic and an antalgic effects.

Keywords:

Antipyretic Effect; Analgesic Effect ; Vernonia Amygdalina; Immunological; Infusions

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