MEG and Pico-Tesla-TMS in Patients with Atrophy with a Double Blind Experimental Design

Authors:

Anninos P¹*, Kotini A¹, Adamopoulos A¹ and Tsagas N²

DOI: 10.23880/nnoaj-16000121

Volume 3, Issue 1

Abstract

We used a whole-head 122 channel MEG system in a magnetically shielded room and a double-blind experimental design to 5 male patients with cerebral atrophy with age ranging from 19-25 years. The pT-TMS was applied to the above patients with magnetic field amplitude (1-7.5pT) and frequency (8-13Hz). Each patient had two separate recording sessions consisting of 3 runs in which we gave real or sham pT-TMS. We then tried to predict the real and sham stimulation sessions based on the changes in the mean peak frequency difference in the 2-7Hz band observed in the patients' brain. After unblinding, there was an increase of frequencies in the range of 2-7 Hz across the subjects followed by a normalization of their MEG. We observed that the results in 4 out of 5 patients were statistically significant (80%). Although our results are preliminary only, they encourage more studies to be conducted.

Keywords:

MEG; Atrophy; pT-TMS

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