Tonic-Clonic Seizure in a Liver-Transplant Recipient due to Concomitant Use of Colchicine with Cyclosporine A and Valganciclovir

Authors:

Iris Wai-Sum Li* and Kenneth Siu-Ho Chok

DOI: 10.23880/jidtm-16000108

Volume 2, Issue 1

Abstract

Use of immunosuppressant was inevitable in post-transplant recipients for prevention and treatment of allograft rejection. Concomitant use of antivirals in prevention of Cytomegalovirus disease after transplantation were common; and reduction in acute allograft rejection and all-cause mortality had also been shown. However, adverse effects from potential interactions between immunosuppressants and antiviral would have been overlooked easily; especially when adverse effects were further potentiated by addition of other medications for trivial conditions. Colchicine was commonly prescribed for clinical gout that occurred at higher incidences in post-transplant recipients on cyclosporine A or tacrolimus. We reported a post-LT patient developed his first tonic-clonic seizure from concomitant use of colchicine with CSA and valganciclovir.

Keywords:

Seizure; Colchicine; Cyclosporine A; Valganciclovir; Liver transplant

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