ISSN: 2640-2653
Tonic-Clonic Seizure in a Liver-Transplant Recipient due to Concomitant Use of Colchicine with Cyclosporine A and Valganciclovir
Use of immunosuppressant was inevitable in post-transplant recipients for prevention and treatment of allograft rejection. Concomitant use of antivirals in prevention of Cytomegalovirus disease after transplantation were common; and reduction in acute allograft rejection and all-cause mortality had also been shown. However, adverse effects from potential interactions between immunosuppressants and antiviral would have been overlooked easily; especially when adverse effects were further potentiated by addition of other medications for trivial conditions. Colchicine was commonly prescribed for clinical gout that occurred at higher incidences in post-transplant recipients on cyclosporine A or tacrolimus. We reported a post-LT patient developed his first tonic-clonic seizure from concomitant use of colchicine with CSA and valganciclovir.
Keywords:
Seizure; Colchicine; Cyclosporine A; Valganciclovir; Liver transplant
Chat with us on WhatsApp