A Comparison of Sterofundin and Ringer’s Lactate on Intraoperative Acid Base and Electrolytes Status in Children: A Randomized Controlled Trial

Authors:

Shariffuddin¹*, Bathumana APP ¹, Adeline C¹, Chinna K² and Lucy C¹

Volume 3, Issue 1

Abstract

Background: Perioperative fluid management of pediatric patients is very challenging, as children are unable to cope
with inappropriate water and electrolyte administration. Suboptimal fluid management leads to deleterious effects on
cardiovascular stability and altered tissue perfusion. We evaluate the Intraoperative use of Sterofundinas the main
crystalloid in moderate to major pediatric surgery in comparison to Ringer’s lactate. The primary outcome was the
changes of plasma pH from the start of surgery to the end of surgery. The secondary outcomes included changes of
Intraoperative plasma electrolyte and Intraoperative hyper/hypoglycemia.
Methodology: A total of 30 children aged between 1-13 years old, were enrolled and randomized into two arms, to
receive Sterofundin or Ringer’s Lactate intraoperatively. Children with renal, cardiac or liver dysfunction, hypervolemia
states, electrolyte imbalance and metabolic acidosis were excluded. Acid-base status, electrolyte balance and
hemodynamic variables were recorded at baseline and repeated every hour until one hour postoperatively.
Results: In Ringer’s Lactate group, the mean difference in pH between the baseline and end of surgery was 0.070.06
(p=0.001, 95% CI 0.03-0.09) and in Sterofundin group the mean difference in pH was 0.050.06 (p=0.010, 95% CI 0.01-
0.08). For base excess (BE), the mean difference in BE between the baseline and end of surgery was-
1.6642.694(p=0.035) in Ringer’s Lactate group while in Sterofundin group the mean difference in BE is -1.331
3.327(p=0.175).
Conclusion: The use of Sterofundin is better to Ringer’s Lactate in the management of Intraoperative acid base,
electrolyte and hemodynamic parameters in pediatric patient undergoing major surgery.

Keywords:

Sterofundin; Ringer’s Lactate; Intraoperative fluid management; Pediatric surgery

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