ISSN: 2640-2653
Prevalence and Clinical Features of Human Bocavirus Infection in Hospitalized Pediatric Patients in a Tertiary Hospital in Oman: Retrospective Study
Background: "Human bocavirus (HBoV) is a new member of the Parvoviridae family". It has been discovered on 2005 from pediatric patients with acute respiratory tract infections (ARTI). The present study is the first study provides prevalence and clinical presentations of HBoV infection among all Royal Hospital (RH) pediatric patients with ARTI and positive HBoV. This study also investigated HBoV co-infection and association with the severity of HBoV manifestations.
Methods: This is a retrospective descriptive study reviewed medical records of all pediatric patients hospitalized in RH with ARI and positive HBoV respiratory tracts samples (nasopharyngeal aspirates, tracheal secretions and Bronchoalveolar lavages) using polymerase chain reaction assay (PCR) from September 2014 to September 2016. All samples were screened for other viruses by PCR HBoV. Clinical presentations and demographic characteristics were investigated .
Result: HBoV PCR was positive in 111 out of 3309 pediatric patients aged from 0 to 13 years presented with ARTI. HBoV Co-infection rate with other virus has been reported in 58.6% of children and the most common co-infected virus is respiratory syncytial virus (28%) followed by rhinovirus (21%) and adenovirus (17.4%). 19.8% of HBoV infected children required pediatric intensive care unit (PICU) admission and 90% of PICU admission required mechanical ventilation. The median age was 12 month. Conclusion: HBoV was detected in 3.35% of children with ARTI. It mainly affects children less than 2 years of age and mainly presents with ARTI. It has high co-infection rate. There was no association between patient’s age, co-infected viruses and severity of clinical presentation, Human, Child, respiratory tract sample, respiratory tract infections, pathogenesis. Advances in Knowledge: 1- This study evaluates the burden of HBoV infection in pediatric patients. 2- It demonstrates a local epidemiological data, clinical presentations and severity of the infection. 3-It shows the outcome of HBoV infection as it is a recently discovered member of Parvoviridae family.Application for the Patient Care: 1-It also reveals the length of hospital stay which has an impact on the social life of the patients and the family. 2-It shows a good outcome of HBoV infection which is important to know when counselling the family. 2-It also emphasizes the need of isolation precaution to prevent the spread of infection to the health care workers and population.
Keywords:
Human Bocavirus; Prevalence; Pediatric
