Effects of Filgrastim on Thrombocytopenia in Patients with Dengue Fever: A Retrospective Study

Authors: Deepak D Baid and Vivika Jain

DOI: 10.23880/vij-16000174

Volume 2, Issue 7

Abstract

Background: Dengue infection causes hematological disturbances including agranulocytosis, leucopenia, and thrombocytopenia. Platelet transfusion is generally used for hematological corrections, but they are not always useful, and are expensive too. Filgrastim is effective in mobilizing the progenitor cells to stimulate the production of platelets and white blood cells (WBCs) endogenously. Aims: This observational, retrospective, single-center study aimed to evaluate the effects of filgrastim in improving platelet and WBC counts in patients with dengue fever. Methods: Data of patients with dengue fever admitted to Nulife Hospital, Mumbai, who had received filgrastim (Neukine®), were analyzed. Dengue was diagnosed by the rapid dengue NS1 antigen and dengue IgM/IgG antibody tests. Patients with severe thrombocytopenia (platelet count :

Keywords: Dengue; Fever; Thrombocytopenia; Platelet; White Blood Cell; Filgrastim; Neukine®

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