Cell Culture Technologies in Successful Biosimilar Development

Authors:

Jun Yuan, Wayne WenYan Xu, Henry XiaoYu Yu, Lothar Yuling Jiang, H Fai Poon*

DOI: 10.23880/beba-16000132

Volume 2, Issue 3

Abstract

The commercial success and expiring patents of biological therapeutics has made biosimilars become attractive to pharmaceutical companies. However, the cost of manufacturing biosimilars has remained a challenge for many companies. Therefore, the ability to mimic the biologically active molecule at the lowest possible cost via cell culture has become the key of successful biosimilar development. Hence, we review current cell culture technologies that are relevant to biosimilar development. The cell line, culture media and bioprocess technology platforms discussed in current review lays a good scientific foundation for the technological competitiveness of biosimilar companies.

Keywords:

Biosimilar; Robust; Cell; Biopharmaceutical

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