ISSN: 2642-6145
Authors: Kafil A*, Mohd R, Bilal H and Shahid AS
Granulomatous inflammation is considered to be an immune mechanism against infections or certain non-neoplastic conditions. Rarely granuloma formation may be noted in neoplastic disorders also. However a granulomatous response in the lymph nodes draining cancers is unusual. Such granulomas may sometimes show tumour cells in their centre. The exact cause of this phenomenon is not known but an immunologic reaction to tumour antigens has been suggested. A close scrutiny of such granuloma is necessary to avoid under diagnosis of a metastatic disease. A subtle morphological feature which may be helpful in differentiating a co-existing infection or tumour induced granuloma needs to be addressed. Granulomatous reactions occurring with carcinomas are a well known but uncommon occurrence. We report a case of 44 year old male with lip ulcer diagnosed as coexistent carcinoma of the lip with tuberculosis. FNAC of the lesions was characterized by the presence of scattered caseating epithelioid cell granulomas along with malignant squamous cells which was confirmed on histopathological examination.
Keywords: Carcinoma; Fine Needle Aspiration Cytology; Lip; Tuberculosis
