ISSN: 2578-4803
Authors: Syed MA, Hanif S*, Syeda Mehwish Ali and Zahid F
The aim of the present study is to investigate the pharmacopoeia limits of ten brands of tablets containing metronidazole 400mg (oral antiprotozoal and antibacterial) sourced from different retail Pharmacy outlets in Lahore region. The quality and pharmaceutical limits of ten different brands of metronidazole tablets were assessed. The assessment included the physical evaluation, disintegration and dissolution tests. All the ten brands of the tablets passed the British Pharmacopoeia (BP) standards for physical appearance. Two of the brands amongst the ten did not comply with the USP specifications for dissolution test and disintegration for metronidazole tablets amongst them one was local and the other belonged to a multinational pharmaceutical company. Only two brands out of the ten analyzed brands of metronidazole tablets passed all the BP, USP quality specifications and were physicochemical equivalent. This study highlighted the need for constant market monitoring of new and marketed products to ascertain their equivalency to the innovator product and to assure that the medicine received to the patient will meet the standards and provide maximum efficacy to the diseased person.
Keywords: Post-market surveillance; In vitro evaluation; Metronidazole brands; Pakistan; Antibiotic brands
