Authors: Radjabova DI*, Alyavi AL, Alyavi BA, Tulyaganova DK, Uzokov JK, Shodiev JD, Yunusova LI, and Nuritdinova SK
This article is about the role of cytokines in the pathogenesis of ischemic myocardial damage. It describes the important role of inflammation in the development of coronary heart disease. The role of individual cytokines in the pathogenesis of coronary artery disease and the most frequent forms of it-angina pectoris. It is shown that TGF-β exhibits its anti-inflammatory properties by inhibiting the synthesis of pro-inflammatory cytokines, such as IL-1α, β, TNF-α. The increase in the level of TGF-β1 as a key profibrotic cytokine leads to the development of fibrosis processes in the walls of the heart and vessels. A decrease in the level of anti-inflammatory cytokines in the blood plasma and an increased content of proinflammatory cytokines and acute phase proteins indicate a higher risk and an unfavorable CVD prognosis.
Keywords: Coronary Heart Disease; Stable Angina; Cytokines
