ISSN: 2578-4838
Authors: Liani M*, Cacciagrano MR, Di Luzio R, Amelio R, Velussi C and Liani R
Aims: The life expectancy of patients with Type II Diabetes Mellitus (T2DM) and Diabetic Foot Syndrome (DFS) is dramatically short. The micro-angiopathy, in relation to endothelium dysfunction, decisively affects the vascular prognosis, perhaps more than macro-angiopathy. Increased availability of nitric oxide (NO) can cause numerous and predictable positive effects in relation to the different mechanisms of macro and micro vascular disease. Methods: We measured NO blood in a group of patients with T2DM on dialysis before and after a Pulsating Electromagnetic Fields (PEMF) cycle and we tested, meanwhile, the reaction of surface receptor platelets GPIb and GPIIb/IIIa. Results: The magnetic field causes an increase in the level of NO, probably due to a prolonged period of exposure, and a modification in the percentage of platelets type and causes a normalisation of the platelets surface receptors in renal patients in dialysis with T2DM. Conclusions: The physical source, although, further investigation is required, can be instrumental in contributing to help with the complications of vascular macro and microcirculation. In our case the increase of NO had caused important effects on haemostasis that can’t be ignored, knowing their role within the pathology of vascular diseases. The antithrombotic drugs prevent acute occlusion of the vessels but do not improve the status of endothelium dysfunction. Antithrombotic drugs prevent acute events but do not improve the related phenomena with poor function of the endothelium. Early tissue aging is a chronic and correlated process with microcirculation and endothelial dysfunction. In our case there is reasonable evidence that it is possible to induce functional improvements of the endothelium in chronic patients characterized by impaired endothelium function.
Keywords: Diabetes; Hemodialysis; Nitric Oxide; Endothelial dysfunction
