TCF7L2 Gene Rs7903146 Polymorphism May Confer Expression of Gestational Diabetes Mellitus in Relatively Young and Lean Mothers

Authors: Mashfiqul H, Sultana N, Jahan S, Panthi S, Aktar Y, Rahman MA, Fariduddin M and Hasanat MA*

DOI: 10.23880/doij-16000132

Volume 1, Issue 3

Abstract

To observe the impact of clinical characteristics and TCF7L2 rs7903146 polymorphism on GDM, pregnant women without history of glucose intolerance [N=100; age 26.22 ± 4.56 years; body mass index (BMI) 26.39 ± 3.85; mean ± SD; GDM=50, normal glucose tolerance (NGT=50) according to WHO 2013 criteria] were studied for TCF7L2 rs7903146 polymorphism using Sanger sequencing technique (genotype CC=63, CT/TT=37) of genotyping. Women with CC and CT/TT genotypes had no significant difference of age (CC vs. CT/TT: 26.10 ± 4.46 vs. 26.43 ± 4.79 years, p=0.723; mean ± SD) or BMI (CC vs. CT/TT: 26.21 ± 3.90 vs. 26.69 ± 3.79 kg/m2, p=0.548; mean ± SD). While GDM women with CC genotype had higher age and BMI than NGT women (GDM vs. NGT: age 27.96 ± 3.79 vs. 24.60 ± 4.45 years, p=0.002; BMI: 27.67 ± 3.93 vs. 25.04 ± 3.50 kg/m2, p=0.006; mean ± SD), GDM women with CT/TT genotype had no significant difference of age and BMI with NGT women (GDM vs. NGT: age 27.00 ± 5.22 vs. 25.60 ± 4.10 years, p=0.390; BMI: 26.48 ± 3.63 vs. 27.00 ± 4.13 kg/m2, p=0.688; mean ± SD). In women of age

Keywords: TCF7L2; GDM; Polymorphism

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