Immunologic Features of Graves’ Disease in Obese Patients

Authors: Fishman B, Zurabov V, Kuprin P, Rumyantsev Y, Nedvetskaya E, Turmakhanov S, Butrimova S, Lole O* and Yukhno M

Volume 2, Issue 11

Abstract

The data presented in the article indicate significant changes in the hormonal background in obese patients with thyroid gland diseases. Various systems are involved: lipid changes in the liver, impaired synthesis and production of thyroid hormones and adrenal glands hormones. More than 30% of the operated patients with Graves’ disease (GD) have obesity of various degrees. Moreover, after surgical treatment of GD, there was a decrease in body weight by 1.3–1.5 times without specific therapy. At the same time, the volume of surgical intervention was regulated individually, including taking into account obesity. The volume of thyroid residue was 3-4 cm3 of gland tissue. In the postoperative period, replacement therapy with L-thyroxine 75-250 mg was administered (the dose was adjusted under the control of T3, T4, TSH in the blood).

Keywords: Graves’ Disease; Obesity; Adrenal Hormones; Thyroid Gland; Antibodies; Autoimmunization

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