ISSN: 2578-4641
Authors: Mohiuddin SS* and Manjrekar P
Orosomucoid is an acute phase protein and is associated with inflammation. Following an acute inflammatory episode increased levels of orosomucoid used to be observed. The clinical value of orosomucoid is currently limited to monitoring the acute phase reaction. The interrelation between cytokine mediated acute inflammatory response and elevation of plasma orosomucoid level of adult type 2 diabetic patients are almost fully established and well recognized but the correlation of inflammatory status with orosomucoid level with glycemic status in adolescent type 1 diabetic patients are still contradictory and under investigation. In this present study we tried to establish the interrelation of orosomucoid level as an indicator of acute inflammatory condition with glycemic status in case of adult as well as adolescent diabetic patients. The plasma levels of orosomucoid were determined for twenty-five newly diagnosed adult type 2 and twelve adolescent type 1 diabetic patients. Thirty normal controls were also chosen matching with age and sex with the patients. Although there are vast variation in results regarding the interrelation between the status of serum orosomucoid level as an low grade chronic inflammatory markers with glycemic status in case of adult as well as adolescent diabetic patient and but after the analysis of data obtained in our present study we can say with conviction that the interrelation of this level are well corelated in case of adult type 2 diabetic patient but in case of adolescent patients its still in contradictory phase and for definitive diagnosis it obviously required further study, investigation and follow up.
Keywords: Type 1 diabetes; Type 2 diabetics chronic low-grade inflammation; α1- acid glycoprotein; Orosomucoid
