Advances in Pharmacology & Clinical Trials (APCT)
ISSN: 2474-9214
Research Article
Screening of Antimicrobial Activity and Cytotoxic Potentiality of
Ethanolic Leaf Extract of Ludwigia adscendens (L.) H.Hara
Abstract
Background: Ludwigia adscendens (L.) H.Hara also known as water primrose which considers as weed in paddy field. Ludwigia species is used as traditional medicine widely and have possibilities to become as a therapeutic agent.
Objective: To evaluate the cytotoxic and antimicrobial potential of using Ludwigia adscendens (L.) H.Hara plant extracts on experimental models in brine shrimp (in vivo) and disk diffusion methods (in vitro) respectively.
Materials and Methods: Acute antimicrobial experiments were performed by disk diffusion method through Determination of zone of inhibition in vitro condition and cytotoxic experiments were performed by brine shrimp lethality bioassay in this present study.
Results: Ludwigia adscendens (L.) H. Hara showed Significant in cytotoxic activity and moderate significant in antimicrobial against all pathogenic strains and activity increase proportionally with dose rate.
Conclusion: These studies conclude that Ludwigia adscendens (L.) H.Hara possesses good cytotoxic activity indicated by LC50 (96.6204¼g/ml) determined by Ldp line probit analysis software and mild antimicrobial activity against some Gram positive and Gram negative bacterial species.
Keywords: Selective Cytotoxicity; Ethanolic Extract; Antimicrobial Activity; Ludwigiaspecies
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