ISSN: 2577-4360
Authors: Umaru IJ*, Umaru HA and Umaru KI
Objective: Type 2 diabetes mellitus is a heterogeneous group of metabolic disorders characterized by persistent hyperglycaemia. The aim of this research work is to gather scientific information about the possibility to utilize the dichloromethane leaf extract of Barringtonia racemosa as an agent of antidiabetic drug. Material and Methods: The Crude extract was obtained through serial extract of five solvents, Hexane, dichloromethane, ethyl acetate, chloroform and methanol while the Assessment of type 2 anti-diabetes was conducted on Streptozotocin (STZ) -induced diabetic albino rats and the data were analysed through one-way ANOVA software. Histopathological studies of the pancreas and kidney were made to get evidence of the β-cell performance and the renal tissue respectively. Results: The streptozotocin (STZ) induced diabetic rats treated with the Dichloromethane extract experienced an antidiabetic effect and the histopathologic observations showed increasing of the granulated β-cell at p<0.001) and no renal tissue damage in the tested rats. Conclusion: The result of this study revealed that the dichloromethane crude extract of Barringtonia racemosa could be utilized as an agent source of type 2 anti-diabetes.
Keywords: Barringtonia racemosa; Dichloromethane; Streptozotocin; Diabetic; Rats
