ISSN: 2642-6145
Authors: Bhuiyan MMA*, Sultana S, Hasan A, Barua D, Ahmed M, Sultana T and Choudhury AA
Background: Coronary artery disease (CAD) is the leading cause of death in type 2 diabetes mellitus (DM) patients. DM is a significant risk factor in atherosclerotic cardiovascular disease (CVD). We aimed to investigate relationship between Neutrophil lymphocyte ratio (NLR) and CAD proven with angiography in type 2 DM and to establish NLR as a useful indicator of CAD in type 2 DM patient. Objective: To assess the NLR as a predictive marker for CAD in patients with type 2 diabetes mellitus. Methods: This case control study was conducted in the Department of Clinical Pathology in collaboration with Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, and Dhaka from March 2014 to February 2015. Total 134 patients were enrolled in this study who were waiting for further percutaneous coronary intervention (PCI) in the Department of Cardiology, BSMMU; 84 cases were considered as Group I (DM with CAD) and 50 controls were Group II (DM without CAD). A 2 ml of blood was collected in EDTA tube from the patients prior to PCI for complete blood count (CBC) were measured by hematology auto analyzer, rechecked manually and NLR was calculated in the Department of Clinical Pathology, BSMMU. Coronary artery disease with 50% coronary artery stenosis and more critical lesion that were diagnosed by PCI were included in this study as cases. Coronary artery disease with less than 50% coronary artery stenosis that was diagnosed by PCI was included in this study as control. The statistical analysis was done by Chi-square test and unpaired sample ‘t’ test. Results: NLR was higher in CAD (+) group compared to group without CAD (-) (2.76 (±0.74) vs 1.56 (±0.15), p<0.001). Conclusion: NLR was higher in DM patients with angiographically proven CAD compared to those DM patients without CAD. NLR may be a useful marker to predict the presence of CAD in type 2 DM patients.
Keywords: Neutrophil lymphocyte ratio; Diabetes mellitus; Coronary artery disease
