ISSN: 2642-1143
Authors: Salem M, Alharbi O, Alhujely A, Abdaljawad Mand Alharbi A*
Systemic lupus erythematosus (SLE) is an autoimmune disease with multisystem complications arising from both underlying disease activity and therapy-related side effects. SLE’s association with lymphoma is a well-established phenomenon. Studies have reported a higher incidence of lymphoma in the SLE population compared with healthy cohorts [1,2]. A 45-year-old woman with systemic lupus erythematosus (SLE) presented with fever, cough, sputum, loss of appetite and fatigue for 4 months. Before that time, her (SLE) symptoms had been well controlled on hydroxyl chloroquine, azathioprine, and small dose prednisone. Physical exam at initial evaluation was remarkable for bilateral inspiratory crackles. Laboratory investigations were normal. Computed tomography to chest showed bilateral cavitary pulmonary nodules and masses. Bronchoscopy with transbronchial biopsy was done. The histopathology showed diffuse large B-cell non-Hodgkin’s lymphoma. Patient referred to oncology service, where they started her on 4 cycles of R-CHOP, followed by 4cycles of high dose chemotherapy (HDCT). She underwent Hematopoietic stem cell transplantation, and achieved complete remissions.
Keywords: Systemic lupus erythematosus (SLE), Diffuse Large B-Cell Non-Hodgkin’s lymphoma.
