ISSN: 2474-9214
Authors: Debjyoti Talukdar, Sanju Aggarwal and Sunil Aggarwal*
Parkinson’s Disease (PD) is a condition which involves impairment due to deterioration of nerve cells or neurons which produce an essential chemical called dopamine. It is associated with body movement along with nerve functioning & muscle coordination. Dopaminergic neurons are susceptible to degeneration in Parkinson’s Disease as massive cell death occurs in the substantia nigra. The relevance of DJ-1 protein is quite important to the pathogenesis of Parkinson’s Disease. Inactivation of DJ-1 protein is related to oxidative stress. Biochemical studies suggest that environmental toxins and pesticides can cause oxidative defects in mitochondrial complex I resulting to neuropathological and neurochemical features of Parkinson’s Disease eventually leading to inactivation or absence of DJ-1 protein. Exercise alters the neuroprotective function of the DJ-1 protein by improving motor functions in Parkinson patients. Decreased DJ-1 protein concentration levels can eventually lead to motor dysfunctions resulting in tremors, rigidity & bradykinesia. Regular exercises involving medical Qigong for kidney, liver, neck along with meditation can play a leading role in reducing the motor symptoms of Parkinson’s Disease. This review will help us to understand the critical relationship between the relevance of exercise and neuroprotective effects of DJ-1 protein in idiopathic Parkinson’s Disease.
Keywords: Parkinson’s Disease; DJ-1 protein; Neurochemical
