Co-Infections Increase the Risk of Pregnancy Outcomes

Authors: Alsamarai AM*, Aljumaili ZKM and Alobaidi AH

Volume 2, Issue 11

Abstract

Background: Infectious pathogens are one of the causal agents for secondary immunosupression and acquired immunosupression due to pathogens is primarily caused by viruses that invade the cellular compartment of the immune system. Aim: To determine whether co-infection of TORCH complex agents increased the development of bad obstetric outcome. Patients and methods: The total number of women included in the study was 538, of them 293 (54.5%) were with BOH, and 245 (45.5%) were with normal pregnancy history. In the BOH group, 144 (49.1%) women were pregnant, while in the normal pregnancy group, 117 (47.7%) were pregnant. IgG and IgM antibodies were detected in sera of all groups using ELISA method. Results: There was a significant frequency difference in seroprevalence of T. gondii, rubella and CMV IgG as indication of co-infection between pregnant BOH, non-pregnant BOH, pregnant normal, and non-pregnant normal. Rubella and CMV co-infections were significantly higher in women with BOH as compared to women with normal pregnancy. OR confirmed such co-infection type and BOH development. Conclusion: TORCH complex agent's co infections were a risk factor that increased development of BOH.

Keywords: TORCH; IgG; IgM; Toxoplasma; Rubella; CMV; HSV; BOH; Co Infection

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